A spin-off titled Lego Marvel's Avengers was released on 26 January 2016, and a sequel titled Lego Marvel Super Heroes 2 was released on 14 November 2017. Lego Marvel Super Heroes received generally positive reviews, and is currently the best-selling Lego video game of all time. The game's storyline sees various heroes from the Marvel Universe joining forces to foil the schemes of Doctor Doom and Loki, who have also recruited a number of villains to aid them, and seek to conquer the Earth using the Doom Ray of Doom, a device built from the shards of the Silver Surfer's board called 'Cosmic Bricks'.

A Nintendo Switch version was released on October 8, 2021.

The handheld version of the game by TT Fusion was released under the title Lego Marvel Super Heroes: Universe in Peril for iOS, Android, Nintendo DS, Nintendo 3DS and PlayStation Vita. The game features gameplay similar to other Lego titles, such as Lego Star Wars: The Complete Saga and Lego Batman 2: DC Super Heroes, alternating between various action adventure sequences and puzzle solving scenarios. Interactive Entertainment for the PlayStation 3, Xbox 360, Wii U, PlayStation 4, Xbox One and Microsoft Windows, and published by Feral Interactive for OS X. Lego Marvel Super Heroes is a 2013 Lego-themed action-adventure video game developed by Traveller's Tales and published by Warner Bros.

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